SB 271046 Hydrochloride | SB 271046A

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Price(USD)

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Quantity

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Product Overview

Product Name	SB 271046 Hydrochloride (Synonyms: SB 271046A)
CAS	209481-24-3
Formula	C20H23Cl2N3O3S2
MW	488.45
Storage condition	4°C, sealed storage, away from moisture

Product details

SB 271046 Hydrochloride (SB 271046A) is a potent, selective and orally active 5-HT6 receptor antagonist with pK_i of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC₅₀=0.16 μM).
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Related literature

Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

PMID: 10928964 PMCID: PMC1572216 DOI: 10.1038/sj.bjp.0703457