Sivelestat Sodium Tetrahydrate | EI546 sodium tetrahydrate | LY544349 sodium tetrahydrate | ONO5046 sodium tetrahydrate | 西维来司钠四水合物

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Price(USD)

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Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Sivelestat Sodium Tetrahydrate \| EI546 sodium tetrahydrate \| LY544349 sodium tetrahydrate \| ONO5046 sodium tetrahydrate
CAS	201677-61-4
Formula	C20H29N2NaO11S
MW	528.51
Appearance	White to off-white powder

Product details

Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC₅₀ of 44 nM and a K_i of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Related literature

A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats.

PMID: 17203197

O-5046, a novel inhibitor of human neutrophil elastase.

PMID: 2049103 DOI: 10.1016/0006-291x(91)91862-7

Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder.

PMID: 18165924 DOI: 10.1007/s11010-007-9698-9

Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

PMID: 32860252 DOI: 10.1111/jcpt.13251