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Product Overview

Product Name	Fostamatinib Disodium;R788 Disodium
CAS	1025687-58-4
Formula	C23H24FN6Na2O9P
MW	624.42
MDL	MFCD15146370
Appearance	White to yellow powder
Storage condition	4°C, sealed storage, away from moisture \| In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Product details

Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

Related literature

Fostamatinib Disodium

PMID: 23284223 PMCID: PMC3533134 DOI: 10.1358/dof.2011.036.04.1588554

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.

PMID: 16946104 DOI: 10.1124/jpet.106.109058

A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes.

PMID: 16452391 DOI: 10.1124/jpet.105.097436

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