Home > Category > Signaling Pathways > TGF-beta/Smad > PKC > PKCδ > Enzastaurin (Synonyms: LY317615)

3-(1-甲基-1H-吲哚-3-基)-4-(1-(1-(2-吡啶甲基)-4-哌啶基)-1H-吲哚-3-基)-1H-吡咯-2,5-二酮；恩扎妥林

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Catalog No：CL1930 CAS No.：170364-57-5 MDLNo：MFCD11040980 Formula：C32 H29 N5 O2 MW：515.60

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Product Overview

Product Name	Enzastaurin (Synonyms: LY317615)
CAS	170364-57-5
Formula	C32 H29 N5 O2
MW	515.60
MDL	MFCD11040980
Appearance	Pink to red powder

Product details

Enzastaurin (LY317615) is an effective inhibitor of PKCβ with an IC50 value of 6 nM. Enzastaurin shows 6-20 times greater selectivity for PKCβ compared to PKCα, PKCγ, and PKCε.

Related literature

Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin.

PMID: 21471986 PMCID: PMC3116015 DOI: 10.1038/jid.2011.70

Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).

PMID: 17023575 PMCID: PMC1794057 DOI: 10.1182/blood-2006-08-042747

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.

PMID: 16103100 DOI: 10.1158/0008-5472.CAN-05-0071

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