INT-777 | S-EMCA | INT 777

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
2 mg	3-5days	￥1968.00	Visible after login	- +
5 mg	3-5days	￥2988.00	Visible after login	- +

Product Overview

Product Name	INT-777 \| S-EMCA \| INT 777
CAS	1199796-29-6
Formula	C27H46O5
MW	450.65
Appearance	White to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Security information

Product details

INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.

Related literature

Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.

PMID: 20014870 DOI: 10.1021/jm901390p

PMID: 19723493 PMCID: PMC2739652 DOI: 10.1016/j.cmet.2009.08.001

PMID: 27259385 PMCID: PMC5083223 DOI: 10.1111/nmo.12866

Biochem Biophys Res Commun. 2018 Sep 3;503(1):38-44.

History

CL2021

INT-777 | S-EMCA | INT 777

1199796-29-6 98+%

CLI1005

Retroprogesterone | (9β,10α)-pregna-4-en-3,20-one

2755-10-4 98+%

6alpha-乙基-23(S)-甲基胆酸

Chemical safety data sheet(MSDS)