Clozapine N-oxide dihydrochloride

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Product Overview

Product Name	Clozapine N-oxide dihydrochloride
CAS	2250025-93-3
Formula	C18H19ClN4O · 2HCl
MW	415.74 \| 342.83(free)
Appearance	Light yellow to yellow powder
Storage condition	4°C, stored under nitrogen

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Product details

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

Related literature

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice.

PMID: 29497149 PMCID: PMC5832819 DOI: 10.1038/s41598-018-22116-z

PMID: 23769625 PMCID: PMC3758874 DOI: 10.1016/j.tips.2013.04.006

PMID: 25822789 PMCID: PMC4476301 DOI: 10.1038/nature14251

PMID: 30038895 PMCID: PMC6053635 DOI: 10.1016/j.mex.2018.03.003

PMID: 31214037 PMCID: PMC6558205 DOI: 10.3389/fphar.2019.00628

History

Clozapine N-oxide dihydrochloride

2250025-93-3 98+%

氯氮平N-氧化盐酸

Chemical safety data sheet(MSDS)