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SNS-032 | BMS-387032

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Catalog No：CL2085 CAS No.：345627-80-7 MDLNo： Formula：C17H24N4O2S2 MW：380.53

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Product Overview

Product Name	SNS-032 (Synonyms: BMS-387032)
CAS	345627-80-7
Formula	C17H24N4O2S2
MW	380.53
Appearance	White to light yellow solid
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2, CDK7, and CDK9 with IC₅₀s of 38 nM, 62 nM and 4 nM, respectively. SNS-032 has antitumor effect.
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Related literature

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

PMID: 19234140 PMCID: PMC2680368 DOI: 10.1182/blood-2008-12-190256

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SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

PMID: 19169685 DOI: 10.1007/s00280-008-0921-5

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SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor.

PMID: 17534442 PMCID: PMC1877978 DOI: 10.1593/neo.07136

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Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells.

PMID: 22447844 DOI: 10.1158/1078-0432.CCR-11-1971

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