Pemetrexed disodium heptahydrate | LY231514 disodium heptahydrate | CAS 357166-29-1

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
500 mg	In-stock	￥500.00	Visible after login	- +
1 g	In-stock	￥800.00	Visible after login	- +
5 g	In-stock	￥1280.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

500 mg

In-stock

￥500.00

Visible after login

- +

1 g

In-stock

￥800.00

Visible after login

- +

5 g

In-stock

￥1280.00

Visible after login

- +

Product Overview

Product Name	Pemetrexed Disodium Heptahydrate \| LY231514 disodium heptahydrate
CAS	357166-29-1
Formula	C20H33N5Na2O13
MW	597.48
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Pemetrexed disodium heptahydrate (LY231514; HSDB7316; LY-231514; HSDB-7316; Alimta), the heptahydrated disodium salt of Pemetrexed and a pyrimidine-based antifolate, is an antifolate and antimetabolite anticancer medication. It targets TS, DHFR, and GARFT with Ki values of 1.3 nM, 7.2 nM, and 65 nM, in that order. In a variety of tumor types, including malignant mesothelioma, NSCLC (non-small cell lung carcinoma), carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder, pemetrexed shows strong antitumor activity.

Related literature

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.

PMID: 9067281

Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma.

PMID: 20548032 DOI: 10.4049/jimmunol.0900437

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History

CL2150B

Pemetrexed Disodium Heptahydrate | LY231514 disodium heptahydrate

357166-29-1 98+%

培美曲赛二钠七水合物

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)