Apricitabine | SPD754 | AVX754

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	￥886.00	Visible after login	- +
5 mg	3-5days	￥1766.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

￥886.00

Visible after login

- +

5 mg

3-5days

￥1766.00

Visible after login

- +

Product Overview

Product Name	Apricitabine \| SPD754 \| AVX754
CAS	160707-69-7
Formula	C8H11N3O3S
MW	229.26

Product details

Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.

Related literature

Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.

PMID: 10428900 PMCID: PMC89378 DOI: 10.1128/AAC.43.8.1835

Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients.

PMID: 16816554 DOI: 10.1097/01.aids.0000232233.41877.63

Sorry, no related items

History

CL2256

Apricitabine | SPD754 | AVX754

160707-69-7 98+%

CL1879

Tamibarotene (Synonyms:Am 80)

94497-51-5 98+%

阿立他滨 | 阿普瑞西他滨

Chemical safety data sheet(MSDS)