Brigatinib | AP-26113 | 布格替尼

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	In-stock	￥166.00	Visible after login	- +
5 mg	In-stock	￥366.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

In-stock

￥166.00

Visible after login

- +

5 mg

In-stock

￥366.00

Visible after login

- +

Product Overview

Product Name	Brigatinib \| AP-26113
CAS	1197953-54-0
Formula	C29H39ClN7O2P
MW	584.09
Appearance	White to light yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.

Related literature

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.

PMID: 27780853 DOI: 10.1158/1078-0432.CCR-16-0569

Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice.

PMID: 27049722 PMCID: PMC5045374 DOI: 10.18632/oncotarget.8508

Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.

PMID: 27144831 DOI: 10.1021/acs.jmedchem.6b00306

Sorry, no related items

History

CL2326

Brigatinib | AP-26113

1197953-54-0 95%