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ABT-737

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Catalog No：CL2344 CAS No.：852808-04-9 MDLNo： Formula：C42H45ClN6O5S2 MW：813.43

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	￥480.00	Visible after login	- +
10 mg	In-stock	￥760.00	Visible after login	- +

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Product Overview

Product Name	ABT-737
CAS	852808-04-9
Formula	C42H45ClN6O5S2
MW	813.43
Appearance	Yellow to orange powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

ABT-737 is an orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.

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CL2344

ABT-737

852808-04-9 95%