Decitabine | 5-Aza-2'-deoxycytidine | 5-AZA-CdR | NSC 127716

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Decitabine (Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716)
CAS	2353-33-5
Formula	C8H12N4O4
MW	228.21
Appearance	White to off white crystalline powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Decitabine is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.

Related literature

Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumorspecific cytotoxic T lymphocyte responses.

PMID: 23671644 PMCID: PMC3650049 DOI: 10.1371/journal.pone.0062924

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.

PMID: 29708513 PMCID: PMC5983332 DOI: 10.1172/JCI97924

The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine.

PMID: 27325794 DOI: 10.1042/BCJ20160302

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