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2-[2,6-二甲基-4-[(1E)-3-[4-(甲硫基)苯基]-3-氧代-1-丙烯-1-基]苯氧基]-2-甲基丙酸

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Catalog No：CL2383 CAS No.：923978-27-2 MDLNo： Formula：C₂₂H₂₄O₄S MW：384.49

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5 mg	In-stock	￥268.00	Visible after login	- +
10 mg	In-stock	￥348.00	Visible after login	- +

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Product Overview

Product Name	Elafibranor \| GFT505
CAS	923978-27-2
Formula	C₂₂H₂₄O₄S
MW	384.49

Product details

Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation.

Related literature

Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.

PMID: 26874076 DOI: 10.1053/j.gastro.2016.01.038

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

PMID: 23703580 DOI: 10.1002/hep.26461

Elafibranor restricts lipogenic and inflammatory responses in a human skin stem cell-derived model of NASH.

PMID: 31028903 DOI: 10.1016/j.phrs.2019.04.016

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