Home > Category > Signaling Pathways > Apoptosis > Caspase > Z-DEVD-FMK | Caspase-3 Inhibitor

N-苄氧羰基-L-alpha-天冬氨酰-L-alpha-谷氨酰-N-[(1S)-3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-缬氨酰胺 1,2-二甲酯

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Catalog No：CL2399 CAS No.：210344-95-9 MDLNo： Formula：C30H41FN4O12 MW：668.66

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	￥768.00	Visible after login	- +
2 mg	3-5days	￥1306.00	Visible after login	- +
5 mg	3-5days	￥2366.00	Visible after login	- +
10 mg	3-5days	￥3566.00	Visible after login	- +
25 mg	3-5days	￥5766.00	Visible after login	- +
50 mg	3-5days	￥7886.00	Visible after login	- +

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Product Overview

Product Name	Z-DEVD-FMK \| Caspase-3 Inhibitor
CAS	210344-95-9
Formula	C30H41FN4O12
MW	668.66
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM.

Related literature

A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.

PMID: 17045926 DOI: 10.1016/j.freeradbiomed.2006.08.016

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Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury.

PMID: 9295387 PMCID: PMC6573442 DOI: 10.1523/JNEUROSCI.17-19-07415.1997

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Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury.

PMID: 15529012 DOI: 10.1097/01.WCB.0000138664.17682.32

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Chemotherapeutic agent CPT-11 eliminates peritoneal resident macrophages by inducing apoptosis.

PMID: 26531131 DOI: 10.1007/s10495-015-1193-2

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