Telaglenastat | CB-839 | 1439399-58-2

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	￥578.00	Visible after login	- +
10 mg	3-5days	￥1088.00	Visible after login	- +

Product Overview

Product Name	Telaglenastat \| CB-839
CAS	1439399-58-2
Formula	C26H24F3N7O3S
MW	571.57
Appearance	Off-white to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Security information

Product details

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.

Related literature

The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.

PMID: 34731180 PMCID: PMC8565744 DOI: 10.1371/journal.pone.0259241

PMID: 24523301 DOI: 10.1158/1535-7163.MCT-13-0870

PMID: 28671190 PMCID: PMC5500878 DOI: 10.1038/ncomms15965

PMID: 31429768 PMCID: PMC6700828 DOI: 10.1186/s12964-019-0412-9

History

CL2411

Telaglenastat | CB-839

1439399-58-2 98+%

CB-839

Chemical safety data sheet(MSDS)