Telaglenastat | CB-839 | 1439399-58-2

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	￥578.00	Visible after login	- +
10 mg	3-5days	￥1088.00	Visible after login	- +

Product Overview

Product Name	Telaglenastat (Synonyms: CB-839)
CAS	1439399-58-2
Formula	C26H24F3N7O3S
MW	571.57
Appearance	Off-white to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

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Product details

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.
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Related literature

The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.

PMID: 34731180 PMCID: PMC8565744 DOI: 10.1371/journal.pone.0259241

PMID: 24523301 DOI: 10.1158/1535-7163.MCT-13-0870

PMID: 28671190 PMCID: PMC5500878 DOI: 10.1038/ncomms15965

PMID: 31429768 PMCID: PMC6700828 DOI: 10.1186/s12964-019-0412-9

History

CL2411

Telaglenastat (Synonyms: CB-839)

1439399-58-2 98+%

CB-839

Chemical safety data sheet(MSDS)