Home > Category > Signaling Pathways > Protein Tyrosine Kinase/RTK > Bcr-Abl > Olverembatinib (GZD824; HQP1351)

4-甲基-N-[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-3-[2-(1H-吡唑并[3,4-b]吡啶-5-基)乙炔基]苯甲酰胺 | 耐克替尼 | 奥雷巴替尼

ChemLeader 98+%

Catalog No：CL2492 CAS No.：1257628-77-5 MDLNo： Formula：C29H27F3N6O MW：532.56

Collect Share

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	3-5days	￥650.00	Visible after login	- +
25 mg	3-5days	￥980.00	Visible after login	- +
50 mg	3-5days	￥1460.00	Visible after login	- +

Chemical safety data sheet(MSDS)

Download MSDS

Inquiry Add To Cart

Product Overview
Related documents
Product details
Related literature

Product Overview

Product Name	Olverembatinib (GZD824; HQP1351)
CAS	1257628-77-5
Formula	C29H27F3N6O
MW	532.56
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of 0.2 and 0.13 nM, respectively. It also displayed good oral bioavailability (48.7%), a reasonable half-life (10.6 h), and promising in vivo antitumor efficacy.

GZD824 induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I).

Related literature

Sorry, there is no relevant literature

Sorry, no related items

History

CL2492

Olverembatinib (GZD824; HQP1351)

1257628-77-5 98+%