Home > Category > Signaling Pathways > Metabolism > Cathepsin > Odanacatib (Synonyms: MK-0822)

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Catalog No：CL2555 CAS No.：603139-19-1 MDLNo： Formula：C25H27F4N3O3S MW：525.56

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	￥1900.00	Visible after login	- +
5 mg	3-5days	￥4180.00	Visible after login	- +

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Product Overview

Product Name	Odanacatib (Synonyms: MK-0822)
CAS	603139-19-1
Formula	C25H27F4N3O3S
MW	525.56
Appearance	White to brown powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Odanacatib (also known as MK-0822) is a potent, neutral, and selective inhibitor of human/rabbit cathepsin K that may be applied to the management of bone metastases and osteoporosis. With IC50s of 0.2 nM/1 nM, it inhibits cathepsin K (human/rabbit) and shows good selectivity against off-target cathepsins B, L, and S. Odanacatib binds to cathepsin K specifically and inhibits its activity. This may reduce bone resorption, improve bone mineral density, and reverse osteoporotic changes. Approximately 16,000 postmenopausal osteoporosis patients are participating in a phase III trial to assess the potential of odanacatib to reduce fracture risk.
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CL2555

Odanacatib (Synonyms: MK-0822)

603139-19-1 98+%