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BLU9931

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Catalog No：CL2721 CAS No.：1538604-68-0 MDLNo： Formula：C26H22Cl2N4O3 MW：509.38

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Product Overview

Product Name	BLU9931
CAS	1538604-68-0
Formula	C26H22Cl2N4O3
MW	509.38
Appearance	Off-white to light yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.

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CL2721

BLU9931

1538604-68-0 98+%