RMC-6236 | RAS-IN-2 | 2765081-21-6

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	￥2366.00	Visible after login	- +
5 mg	3-5 days	￥5788.00	Visible after login	- +
10 mg	3-5 days	￥9388.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5 days

￥2366.00

Visible after login

- +

5 mg

3-5 days

￥5788.00

Visible after login

- +

10 mg

3-5 days

￥9388.00

Visible after login

- +

Product Overview

Product Name	RMC-6236 (Synonyms: RAS-IN-2)
CAS	2765081-21-6
Formula	C43H56N8O5S
MW	797.02
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors.
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Related literature

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.

PMID: 38593348 PMCID: PMC11149917 DOI: 10.1158/2159-8290.CD-24-0027

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