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1-(4-(苄基氨基)-7,8-二氢-5H-吡喃并[4,3-d]嘧啶-2-基)-2-甲基-1H-吲哚-4-甲酰胺 ;CB-5083

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Catalog No：CL2799 CAS No.：1542705-92-9 MDLNo：MFCD28963914 Formula：C24H23N5O2 MW：413.47

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	￥336.00	Visible after login	- +
5 mg	3-5 days	￥866.00	Visible after login	- +
10 mg	3-5 days	￥1288.00	Visible after login	- +

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Product Overview

Product Name	CB-5083
CAS	1542705-92-9
Formula	C24H23N5O2
MW	413.47
MDL	MFCD28963914
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

CB-5083 is a first-in-class, potent, and orally bioavailable p97 inhibitor with a D2 site IC50 of 11 nM. It disrupts protein homeostasis, showing anti-tumor effects in solid and hematological cancers, and is more potent than current proteasome inhibitors.

Related literature

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).

J Med Chem. 2015 Dec 24;58(24):9480-97.

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CL2799

CB-5083

1542705-92-9 98+%