Home > Category > Signaling Pathways > Metabolism > Isocitrate Dehydrogenase (IDH) > Vorasidenib | AG-881

6-(6-氯-2-吡啶基)-N2,N4-双[(1R)-2,2,2-三氟-1-甲基乙基]-1,3,5-三嗪-2,4-二胺

ChemLeader 98+%
Catalog No:CL2881 CAS No.:1644545-52-7 MDLNo: Formula:C14H13ClF6N6 MW:414.74
Size Availability Price(USD) VIP Price (USD) Quantity
2 mg In-stock ¥526.00 Visible after login
- +
5 mg In-stock ¥966.00 Visible after login
- +
10 mg In-stock ¥1638.00 Visible after login
- +

Chemical safety data sheet(MSDS)

Download MSDS

Certificate Of Authenticity(CPA)

  • Product Overview
  • Related documents
  • Product details
  • Related literature
Product Overview
Product Name Vorasidenib | AG-881
CAS1644545-52-7
FormulaC14H13ClF6N6
MW414.74
AppearanceWhite to off-white
Product details

Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K .


Related
Sorry, no related items
Service
ChemLeader
021-58180488
Online service time: 9:00-18:00 on weekdays