1241946-89-3 | Simeprevir sodium | TMC435 sodium | TMC435350 sodium

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Product Overview

Product Name	Simeprevir sodium \| TMC435 sodium \| TMC435350 sodium \| Olysio
CAS	1241946-89-3
Formula	C38H47N5O7S2.XNa
MW	749.94 (free)

Product details

Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (M^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.

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