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妥卡替尼 | 图卡替尼

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Catalog No：CL2895 CAS No.：937263-43-9 MDLNo： Formula：C26H24N8O2 MW：480.52

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	￥436.00	Visible after login	- +
10 mg	3-5days	￥688.00	Visible after login	- +
25 mg	3-5days	￥1066.00	Visible after login	- +

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Product Overview

Product Name	Tucatinib \| Irbinitinib \| ARRY-380 \| ONT-380
CAS	937263-43-9
Formula	C26H24N8O2
MW	480.52
Appearance	White to yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC₅₀ of 8 nM.

Related literature

Phase 1 Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+ Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC).

PMID: 28053022 DOI: 10.1158/1078-0432.CCR-16-1496

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Abstract: In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research;

https://doi.org/10.1158/1538-7445.AM2012-852

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In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with RP-56976.

https://doi.org/10.1158/0008-5472.SABCS-09-5104

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