Home > Category > Signaling Pathways > Cytoskeletal Signaling > Integrin > Tirofiban (Synonyms: L700462; MK383)

替罗非班 | L700462 | MK383

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Catalog No：CL2903A CAS No.：144494-65-5 MDLNo： Formula：C22H36N2O5S MW：440.60

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Product Overview

Product Name	Tirofiban (Synonyms: L700462; MK383)
CAS	144494-65-5
Formula	C22H36N2O5S
MW	440.60
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.

Related literature

Tirofiban induces VEGF production and stimulates migration and proliferation of endothelial cells.

PMID: 24751361 DOI: 10.1016/j.vph.2014.04.002

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Effects of tirofiban on the reperfusion-related no-reflow in rats with acute myocardial infarction.

PMID: 23610574 PMCID: PMC3627702 DOI: 10.3969/j.issn.1671-5411.2013.01.009

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The effect of tirofiban on microvascular thrombosis: crush model.

PMID: 15988269 DOI: 10.1097/01.prs.0000169938.26534.97

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