R547 | Ro 4584820 | 741713-40-6

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	R547 \| Ro 4584820
CAS	741713-40-6
Formula	C18H21F2N5O4S
MW	441.45
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with K_i of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases.

Related literature

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.

PMID: 17121911 DOI: 10.1158/1535-7163.MCT-06-0355

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.

PMID: 17064073 DOI: 10.1021/jm0606138

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks.

PMID: 22651900 PMCID: PMC3433335 DOI: 10.1186/1752-0509-6-54

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History

CL2946

R547 | Ro 4584820

741713-40-6 98+%