Ruxolitinib | INCB018424 | Ruxolitinib Free base

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Ruxolitinib \| INCB018424 \| Ruxolitinib Free base \| (R)-Ruxolitinib
CAS	941678-49-5
Formula	C17H18N6
MW	306.37
Appearance	White to light yellow powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Related literature

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

PMID: 20130243 PMCID: PMC3953826 DOI: 10.1182/blood-2009-04-214957

Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic.

PMID: 27379204 PMCID: PMC4904019 DOI: 10.3389/fonc.2016.00142

Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model.

PMID: 29515770 PMCID: PMC5839401 DOI: 10.18632/oncotarget.24267

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History

CL2956

Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib

941678-49-5 98+%

鲁索替尼 | 鲁索利替尼 | 芦可替尼

Chemical safety data sheet(MSDS)