Home > Category > Signaling Pathways > Apoptosis > Apoptosis > MK-2206 dihydrochloride | MK-2206 ·2HCl

8-(4-(1-氨基环丁基)苯基)-9-苯基-[1,2,4]三唑并[3,4-f][1,6]萘啶-3(2H)-酮二盐酸盐

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Catalog No：CL3096 CAS No.：1032350-13-2 MDLNo：MFCD14584463 Formula：C25H23N5O· 2HCl MW：482.40

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Product Overview

Product Name	MK-2206 dihydrochloride \| MK-2206 ·2HCl
CAS	1032350-13-2
Formula	C25H23N5O· 2HCl
MW	482.40
MDL	MFCD14584463
Appearance	Yellow powder
Storage condition	4°C, sealed storage, away from moisture

Product details

MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC₅₀s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy.

Related literature

Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo.

PMID: 25336925 PMCID: PMC4199975 DOI: 10.2147/DDDT.S67961

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Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer.

PMID: 24581231 PMCID: PMC3941258 DOI: 10.1186/1471-2407-14-145

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