| Product Name | PLX5622 | 
|---|---|
| CAS | 1303420-67-8 | 
| Formula | C21H19F2N5O | 
| MW | 395.41 | 
| MDL | MFCD32201039 | 
| Size | Availability | Price(USD) | VIP Price (USD) | Quantity | 
|---|---|---|---|---|
| 1 mg | 3-5 days | ¥366.00 | Visible after login | |
| 5 mg | 3-5 days | ¥966.00 | Visible after login | |
| 10 mg | 3-5 days | ¥1366.00 | Visible after login | |
| 25 mg | 3-5 days | ¥2286.00 | Visible after login | 
| Product Name | PLX5622 | 
|---|---|
| CAS | 1303420-67-8 | 
| Formula | C21H19F2N5O | 
| MW | 395.41 | 
| MDL | MFCD32201039 | 
PLX5622, a highly selective CSF-1R inhibitor with an IC50 of < 10 nmol/L and over 20-fold selectivity over KIT and FLT3, is a brain-penetrant, orally active compound with an IC50 of 0.016 μM and a Ki of 5.9 nM. It enables targeted microglial cell elimination during pathology development and exhibits favorable pharmacokinetics across multiple animal species.
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PMID: 31434879 PMCID: PMC6704256 DOI: 10.1038/s41467-019-11674-z
Negative feedback control of neuronal activity by microglia.
PMID: 32999463 PMCID: PMC7577179 DOI: 10.1038/s41586-020-2777-8
https://doi.org/10.1016/j.bbih.2019.100010