buy Lapaquistat acetate| Lapaquistat acetatesupplier | purchase Lapaquistat acetate ；(Synonyms: TAK-475); CAS: 189060-13-7; squalene synthase inhibitor

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5 days	￥1488.00	Visible after login	- +
2 mg	3-5 days	￥2266.00	Visible after login	- +
5 mg	3-5 days	￥3626.00	Visible after login	- +

Size

Availability

Price(USD)

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Quantity

1 mg

3-5 days

￥1488.00

Visible after login

- +

2 mg

3-5 days

￥2266.00

Visible after login

- +

5 mg

3-5 days

￥3626.00

Visible after login

- +

Product Overview

Product Name	Lapaquistat acetate (Synonyms: TAK-475)
CAS	189060-13-7
Formula	C33H41ClN2O9
MW	645.14
MDL	MFCD06407873
Appearance	White to off-white powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

Lapaquistat acetate, a potent squalene synthase inhibitor, impedes the conversion of farnesyl diphosphate (FPP) to squalene, a key step in cholesterol synthesis. Utilized in treating Mevalonate Kinase Deficiency (MKD), an autosomal recessive disorder, it significantly reduces low-density lipoprotein cholesterol levels. However, its use may be accompanied by liver damage, a known side effect that warrants monitoring.

Related literature

Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice

PMID: 28901277 DOI: 10.2174/0929867324666170911161417

Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions.

Br J Pharmacol. 2008 Jul;154(5):949-57.

Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia.

PMID: 21518985 DOI: 10.1161/CIRCULATIONAHA.110.975284

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History

CL3134

Lapaquistat acetate (Synonyms: TAK-475)

189060-13-7 98+%

2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氢苯并[e][1,4]氧氮杂卓-3-基)乙酰基)哌啶-4-基)乙酸

Chemical safety data sheet(MSDS)