Home > Category > Signaling Pathways > JAK/STAT Signaling > JAK > Pyridone 6 (Synonyms: JAK Inhibitor I; CMP 6; Janus-Associated Kinase Inhibitor I)

吡啶酮6; 2-(叔丁基)-9-氟-1,6-二氢-7H-苯并[h]咪唑并[4,5-f]异喹啉-7-酮

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Catalog No：CL3788 CAS No.：457081-03-7 MDLNo： Formula：C18H16FN3O MW：309.34

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Product Overview

Product Name	Pyridone 6 (Synonyms: JAK Inhibitor I; CMP 6; Janus-Associated Kinase Inhibitor I)
CAS	457081-03-7
Formula	C18H16FN3O
MW	309.34

Product details

Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

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CL3788

Pyridone 6 (Synonyms: JAK Inhibitor I; CMP 6; Janus-Associated Kinase Inhibitor I)

457081-03-7