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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	￥566.00	Visible after login	- +
20 mg	In-stock	￥948.00	Visible after login	- +

Product Overview

Product Name	Triptolide (PG490)
CAS	38748-32-2
Formula	C20H24O6
MW	360.40
MDL	MFCD00210565
Appearance	white solid powder
Storage condition	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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Product details

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

Related literature

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ.

PMID: 34108030 PMCID: PMC8188724 DOI: 10.1186/s13046-021-01995-7