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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	In-stock	￥566.00	Visible after login	- +
20 mg	In-stock	￥948.00	Visible after login	- +

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Availability

Price(USD)

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10 mg

In-stock

￥566.00

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20 mg

In-stock

￥948.00

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Product Overview

Product Name	Triptolide (PG490)
CAS	38748-32-2
Formula	C20H24O6
MW	360.40
MDL	MFCD00210565
Appearance	white solid powder
Storage condition	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Product details

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

Related literature

Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ.

PMID: 34108030 PMCID: PMC8188724 DOI: 10.1186/s13046-021-01995-7

Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.

PMID: 27999372 PMCID: PMC5187939 DOI: 10.3390/ijms17122139

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.

PMID: 26134275 PMCID: PMC4488747 DOI: 10.1038/srep11747

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History

HL1019

Triptolide (PG490)

38748-32-2 98+%

雷公藤甲素 (雷藤素甲；雷公藤内酯醇；雷公藤多甙)

Chemical safety data sheet(MSDS)

Certificate Of Authenticity(CPA)