Ruscogenin | 472-11-7 | 鲁斯可皂苷元

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Price(USD)

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Product Overview

Product Name	Ruscogenin
CAS	472-11-7
Formula	C27H42O4
MW	430.62
Appearance	White to off-white powder
Storage condition	4°C, protect from light

Product details

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities. Ruscogenin has orally bioactivity.

Related literature

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.

PMID: 27589720 PMCID: PMC5037697 DOI: 10.3390/ijms17091418

Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB.

PMID: 18946195 DOI: 10.1254/jphs.08083fp

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