Home > Category > Signaling Pathways > GPCR & G Protein > Adenosine Receptor > MRS 1523 (Synonyms: 3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate)

6-乙基-5-((乙硫基)羰基)-2-苯基-4-丙基烟酸丙酯

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Catalog No:CL1065 CAS No.:212329-37-8 MDLNo: Formula:C23H29NO3S MW:399.55
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Product Overview
Product Name MRS 1523 (Synonyms: 3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate)
CAS212329-37-8
FormulaC23H29NO3S
MW399.55
AppearanceYellowish brown oil
Storage conditionDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
Product details

MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells  and human coronary smooth muscle cells. 
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