Home > Category > Signaling Pathways > Epigenetics > Epigenetic Reader Domain > A-485; N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide

N-(4-氟苄基)-2-((R)-5-(3-甲基脲基)-2',4'-二氧代-2,3-二氢螺[茚-1,5'-恶唑烷]-3'-基)-N-((S)-1,1,1-三氟丙-2-基)乙酰胺

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Catalog No：CL1256 CAS No.：1889279-16-6 MDLNo： Formula：C25H24F4N4O5 MW：536.48

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	￥536.00	Visible after login	- +
5 mg	3-5days	￥1368.00	Visible after login	- +

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Product Overview

Product Name	A-485; N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide
CAS	1889279-16-6
Formula	C25H24F4N4O5
MW	536.48
Appearance	White to off-white powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP (IC50=9.8/2.6 nM) selectively. A-485 has antitumor effects, including several hematologic malignancies and androgen receptor-positive prostate cancer.

Related literature

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

PMID: 28953875 PMCID: PMC6050590 DOI: 10.1038/nature24028

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A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL.

PMID: 32173363 DOI: 10.1016/j.bcp.2020.113914

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