Vicriviroc maleate (Synonyms: SCH-417690 maleate ; SCH-D maleate) ; 维立韦罗马来酸盐 ; CAS 599179-03-0

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Product Overview

Product Name	Vicriviroc maleate (Synonyms: SCH-417690 maleate ; SCH-D maleate; 维立韦罗马来酸盐）
CAS	599179-03-0
Formula	C28H38F3N5O2·C4H4O4
MW	649.70 \| 533.64(free)
MDL	MFCD09833218
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment of HIV-1.

Related literature

Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1.

PMID: 16304152 PMCID: PMC1315929 DOI: 10.1128/AAC.49.12.4911-4919.2005

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.

PMID: 15115380 DOI: 10.1021/jm0304515

Effect of Vicriviroc on the QT/Corrected QT Interval and Central Nervous System in Healthy Subjects.

PMCID: PMC2876383 PMID: 20350942

Science Direct: Novel targets for anti-retroviral therapy.

https://doi.org/10.1016/j.jinf.2009.09.014

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History

CL3097