Omipalisib | GSK2126458 | GSK458

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	￥336.00	Visible after login	- +
10 mg	3-5days	￥576.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

3-5days

￥336.00

Visible after login

- +

10 mg

3-5days

￥576.00

Visible after login

- +

Product Overview

Product Name	Omipalisib \| GSK2126458 \| GSK458
CAS	1086062-66-9
Formula	C25H17F2N5O3S
MW	505.50
Appearance	Off-white to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy.

Related literature

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.

PMID: 22389471 DOI: 10.1158/1535-7163.MCT-11-0989

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.

PMID: 24900173 PMCID: PMC4007793 DOI: 10.1021/ml900028r

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

PMID: 23899692 PMCID: PMC3800496 DOI: 10.1021/cb400430t

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History

CL1337

Omipalisib | GSK2126458 | GSK458

1086062-66-9 98+%