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凡德他尼

Catalog No：CL1896 CAS No.：443913-73-3 MDLNo： Formula：C22H24BrFN4O2 MW：475.35

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Product Overview

Product Name	Vandetanib (ZD6474)
CAS	443913-73-3
Formula	C22H24BrFN4O2
MW	475.35
Appearance	White Powder

Product details

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS).