Motesanib (Synonyms: AMG 706；莫替沙尼 ) CAS: 453562-69-1

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Product Overview

Product Name	Motesanib (Synonyms: AMG 706；莫替沙尼 )
CAS	453562-69-1
Formula	C22H23N5O
MW	373.45
MDL	MFCD10567689
Appearance	White to khaki powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

Related literature

Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors.

PMID: 19118038 DOI: 10.1158/1078-0432.CCR-08-1155

AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts.

PMID: 16951187 DOI: 10.1158/0008-5472.CAN-05-4665

Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors.

PMID: 20507929 PMCID: PMC3216115 DOI: 10.1158/1078-0432.CCR-09-3385

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History

CL2094

Motesanib (Synonyms: AMG 706；莫替沙尼 )

453562-69-1 98+%