Sitaxsentan sodium | TBC11251 sodium salt | TBC11251

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Product Overview

Product Name	Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium)
CAS	210421-74-2
Formula	C18H14ClN2NaO6S2
MW	476.89
Appearance	Light yellow to yellow powder
Storage condition	4°C, sealed storage, away from moisture

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Product details

Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH.

Related literature

Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.

PMID: 20628435 DOI: 10.1139/Y10-060