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乌帕替尼

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Catalog No：CL2247 CAS No.：1310726-60-3 MDLNo： Formula：C₁₇H₁₉F₃N₆O MW：380.37

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Product Overview

Product Name	ABT-494(Upadacitinib) Free base
CAS	1310726-60-3
Formula	C₁₇H₁₉F₃N₆O
MW	380.37
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

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CL2247

ABT-494(Upadacitinib) Free base

1310726-60-3 95%