Retatrutide | LY3437943 | CAS 2381089-83-2

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Product Overview

Product Name	Retatrutide \| LY3437943
CAS	2381089-83-2
Formula	C221H342N46O68
MW	4731.33
Appearance	White to off-white powder
Storage condition	Dry, dark and at -20 ℃ for 1 year or -80 ℃ for 2 years

Product details

Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide binds human GCGR, GIPR, and GLP-1R with EC₅₀ values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity.

Related literature

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.

PMID: 35985340 DOI: 10.1016/j.cmet.2022.07.013

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