Home > Category > Signaling Pathways > Protein Tyrosine Kinase/RTK > Src > Tesevatinib (Synonyms: XL-647; EXEL-7647; KD-019)

Tesevatinib (XL-647)

ChemLeader 98+%

Catalog No：CL2250 CAS No.：781613-23-8 MDLNo：MFCD22124889 Formula：C24H25Cl2FN4O2 MW：491.39

Collect Share

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Chemical safety data sheet(MSDS)

Download MSDS

Inquiry Add To Cart

Product Overview
Related documents
Product details
Related literature

Product Overview

Product Name	Tesevatinib (Synonyms: XL-647; EXEL-7647; KD-019)
CAS	781613-23-8
Formula	C24H25Cl2FN4O2
MW	491.39
MDL	MFCD22124889

Product details

Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity.

Related literature

Sorry, there is no relevant literature

Sorry, no related items

History

CL2250

Tesevatinib (Synonyms: XL-647; EXEL-7647; KD-019)

781613-23-8 98+%