Capecitabine | RO 09-1978 | Xeloda | CAS 154361-50-9 | DNA/RNA Synthesis inhibitor

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Availability

Price(USD)

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Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Capecitabine \| RO 09-1978 \| Xeloda
CAS	154361-50-9
Formula	C15H22FN3O6
MW	359.35
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.

Related literature

Capecitabine: A review.

https://doi.org/10.1016/j.clinthera.2005.01.005

Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity.

PMID: 18077151 DOI: 10.1016/j.ejca.2007.10.023

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History

CL2563

Capecitabine | RO 09-1978 | Xeloda

卡培他滨

Chemical safety data sheet(MSDS)