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富马酸卢帕他定

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Catalog No：CL2641 CAS No.：182349-12-8 MDLNo： Formula：C26H26ClN3·C4H4O4 MW：532.03 | 415.97(free)

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Product Overview

Product Name	Rupatadine Fumarate \| UR-12592 Fumarate
CAS	182349-12-8
Formula	C26H26ClN3·C4H4O4
MW	532.03 \| 415.97(free)
Appearance	White to off-white powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Rupatadine is an inhibitor of PAFR and histamine (H1) receptor with K_i of 550 nM and 102 nM, respectively.

Related literature

Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).

PMID: 8996188

Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents.

PMID: 23869224 PMCID: PMC3711902 DOI: 10.1371/journal.pone.0068631

In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1.

PMID: 10959557 DOI: 10.1007/PL00000216

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