Home > Category > Signaling Pathways > Immunology & Inflammation > COX(Cyclooxygenase) > NS-398(Synonyms: N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide )

N-[2-(环己基氧基)-4-硝基苯基]甲烷磺酰胺

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Catalog No：CL2660 CAS No.：123653-11-2 MDLNo：MFCD00882995 Formula：C13H18N2O5S MW：314.36

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Product Overview

Product Name	NS-398(Synonyms: N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide )
CAS	123653-11-2
Formula	C13H18N2O5S
MW	314.36
MDL	MFCD00882995
Appearance	Light yellow to yellow powder

Product details

NS-398 is a non-steroidal anti-inflammatory drug with analgesic properties, which can be used in the study of pain relief. It selectively inhibits the activity of COX-2 with an IC50 value of 3.8 μM and has no effect on the activity of COX-1 at a concentration of 100 μM.

Related literature

A Research Article Submitted to Journal of Ethnopharmacology Naoxintong restores Ischemia Injury and inhibits Thrombosis via COX2-VEGF/NFκB Signaling[J].

https://doi.org/10.1016/j.jep.2021.113809

All-trans retinoic acid and COX-2 cross-talk to regulate BMP9-induced osteogenic differentiation via Wnt/β-catenin in mesenchymal stem cells[J].

https://doi.org/10.1016/j.biopha.2019.109279

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro.

PMID: 8140262 DOI: 10.1016/0090-6980(94)90074-4

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.

Gen Pharmacol. 1993 Jan;24(1):105-10.

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