Home > Category > Signaling Pathways > Immunology & Inflammation > Salt-inducible Kinase (SIK) > HG-9-91-01 | SIK inhibitor 1

HG-9-91-01 | SIK inhibitor 1

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Catalog No：CL2905 CAS No.：1456858-58-4 MDLNo： Formula：C32H37N7O3 MW：567.68

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	￥688.00	Visible after login	- +
5 mg	3-5days	￥1658.00	Visible after login	- +
10 mg	3-5days	￥2988.00	Visible after login	- +

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Product Overview

Product Name	HG-9-91-01 \| SIK inhibitor 1
CAS	1456858-58-4
Formula	C32H37N7O3
MW	567.68
Appearance	White to yellow powder
Storage condition	White to yellow powder

Product details

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC₅₀s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

Related literature

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.

PMID: 25114223 PMCID: PMC4151730 DOI: 10.1073/pnas.1412308111

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The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

PMID: 25114223 PMCID: PMC4151730 DOI: 10.1073/pnas.1412308111

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Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages.

PMID: 23033494 PMCID: PMC3479463 DOI: 10.1073/pnas.1215450109

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