Oxaliplatin | L-OHP | CAS 61825-94-3

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Price(USD)

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Product Overview

Product Name	Oxaliplatin \| L-OHP
CAS	61825-94-3
Formula	C8H14N2O4 Pt
MW	397.29
Appearance	White or almost white crystalline powder
Storage condition	4°C, protect from light

Product details

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autophagy.

Related literature

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity[J].

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation[J].

KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3β signaling[J].

PMID: 33995648 PMCID: PMC8120193 DOI: 10.7150/jca.52103

The synergistic effects of oxaliplatin and piperlongumine on colorectal cancer are mediated by oxidative stress.

PMID: 31395855 PMCID: PMC6687721 DOI: 10.1038/s41419-019-1824-6

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History

Cycloastragenol | Cyclosiversigenin | Astramembrangenin | Cyclosieversigenin

78574-94-4 98+%

奥沙利铂

Chemical safety data sheet(MSDS)