Ruxolitinib sulfate | INCB018424 sulfate | 1092939-16-6 | 鲁索替尼硫酸盐

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	Ruxolitinib sulfate \| INCB018424 sulfate
CAS	1092939-16-6
Formula	C17H18N6 · H2SO4
MW	404.44 \| 306.37(free)
Appearance	Off-white to gray powder
Storage condition	4°C, sealed storage, away from moisture

Product details

Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC₅₀s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.

Related literature

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.

PMID: 20130243 PMCID: PMC3953826 DOI: 10.1182/blood-2009-04-214957

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis.

PMID: 22375970 DOI: 10.1056/NEJMoa1110556

JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis.

PMID: 22375970 DOI: 10.1056/NEJMoa1110556