TW-37 | CAS 877877-35-5

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Product Overview

Product Name	TW-37
CAS	877877-35-5
Formula	C33H35NO6S
MW	573.70
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.

Related literature

Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.

PMID: 16951185 DOI: 10.1158/0008-5472.CAN-05-3691

Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

PMID: 17404107 DOI: 10.1158/1078-0432.CCR-06-1574

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