HA14-1 ;CAS:65673-63-4

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Availability

Price(USD)

VIP Price (USD)

Quantity

There is no price information at the moment, you can send an inquiry,and we will reply to you as soon as possible.

Product Overview

Product Name	HA14-1
CAS	65673-63-4
Formula	C17H17BrN2O5
MW	409.23
MDL	MFCD00218213
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).

Related literature

Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1.

PMID: 17055152 PMCID: PMC1924967 DOI: 10.1016/j.canlet.2006.09.009

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

PMID: 16510597 DOI: 10.1158/0008-5472.CAN-05-2097

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.

PMID: 10860979 PMCID: PMC16510 DOI: 10.1073/pnas.97.13.7124

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Chemical safety data sheet(MSDS)