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rel-(αR,4R)-2-氨基-6-溴-4-(1-氰基-2-乙氧基-2-甲酰)-4H-苯并呋喃-3-羧酸

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Catalog No：CL3112 CAS No.：65673-63-4 MDLNo：MFCD00218213 Formula：C17H17BrN2O5 MW： 409.23

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Product Overview

Product Name	HA14-1
CAS	65673-63-4
Formula	C17H17BrN2O5
MW	409.23
MDL	MFCD00218213
Appearance	White to light yellow powder
Storage condition	Store short-term at 0-4°C or long-term at -20°C in a dry, dark place.

Product details

HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).

Related literature

Initiation of apoptosis and autophagy by the Bcl-2 antagonist HA14-1.

PMID: 17055152 PMCID: PMC1924967 DOI: 10.1016/j.canlet.2006.09.009

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

PMID: 16510597 DOI: 10.1158/0008-5472.CAN-05-2097

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.

PMID: 10860979 PMCID: PMC16510 DOI: 10.1073/pnas.97.13.7124

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